Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

Hybrid sterility is one of the reproductive isolation mechanisms leading to speciation. Prdm9, the only known vertebrate hybrid-sterility gene, causes failure of meiotic chromosome synapsis and infertility in male hybrids that are the offspring of two mouse subspecies. Within species, Prdm9 determin...

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Bibliographic Details
Main Authors: Sona Gregorova, Vaclav Gergelits, Irena Chvatalova, Tanmoy Bhattacharyya, Barbora Valiskova, Vladana Fotopulosova, Petr Jansa, Diana Wiatrowska, Jiri Forejt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
homology-dependent meiotic chromosome pairing
synaptonemal complex
Prdm9
speciation
Online Access:https://elifesciences.org/articles/34282

Internet

https://elifesciences.org/articles/34282

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