Combined Transcriptomics and Metabolomics in a Rhesus Macaque Drug Administration Study

Combined Transcriptomics and Metabolomics in a Rhesus Macaque Drug Administration Study

We describe a multi-omic approach to understanding the effects that the anti-malarial drug pyrimethamine has on immune physiology in rhesus macaques (Macaca mulatta). Whole blood and bone marrow RNA-Seq and plasma metabolome profiles (each with over 15,000 features) have been generated for five naï...

Full description

Bibliographic Details
Main Authors: Kevin J. Lee, Weiwei eYin, Dalia eArafat, Yan eTang, Karan eUppal, ViLinh eTran, Monica eCabrera-Mora, Stacey eLapp, Alberto eMoreno, Esmeralda eMeyer, Jeremy eDeBarry, Suman ePakala, Vishal eNayak, Jessica eKissinger, Dean P. Jones, Mary eGalinski, Mark eStyczynski, Greg eGibson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Bone Marrow
Peripheral Blood Stem Cell Transplantation
Pyrimethamine
principal component analysis (PCA)
axes of variation
bayesian network inference
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00054/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00054/full

Similar Items