Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling

Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling

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Chronic obstructive pulmonary disease (COPD) is associated with inflammatory cell reactions, tissue destruction and lung remodeling. Many signaling pathways for these phenomena are still to be identified. We developed a mouse model of COPD to evaluate some pathophysiological mechanisms acting during...

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Bibliographic Details
Main Authors: P.J.C. Biselli, F.D.T.Q.S. Lopes, H.T. Moriya, D.H.R.F. Rivero, A.C. Toledo, P.H.N. Saldiva, T. Mauad, M.A. Martins
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Emphysema
Cigarette smoke
Airways
TGF-β1
Mouse airway epithelium remodeling
Proximal airspace enlargements
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500012

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