The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53

The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53

Hepatocellular carcinoma (HCC) is a common malignancy associated with a high risk of recurrence and metastasis and a poor prognosis. Here, we examined the involvement of the pseudokinase Tribbles 1 (TRIB1), a scaffold protein associated with several malignancies, in HCC and investigated the underlyi...

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Bibliographic Details
Main Authors: Ying Ye, Guangdong Wang, Guoyu Wang, Juhua Zhuang, Saifei He, Yanan Song, Jing Ni, Wei Xia, Jiening Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
hepatocellular carcinoma
Tribbles 1
microRNA-23a
tumor suppressor p53
β-catenin signaling pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00789/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00789/full

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