Aldosterone synthase gene polymorphism and renal histopathologic changes in kidney transplant patients receiving a calcineurin inhibitor

Aldosterone synthase gene polymorphism and renal histopathologic changes in kidney transplant patients receiving a calcineurin inhibitor

Introduction: Aldosterone participates in the pathogenesis of calcineurin inhibitor nephrotoxicity (CIN), producing renal vasoconstriction and transforming growth factor beta (TGFß) expression. The objective of this study was to assess aldosterone polymorphisms and relationships to plasma aldosteron...

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Main Authors: Patricia C Ruiz-Palacios, Francisco E Rodríguez-Castellanos, Eduardo Mancilla-Urrea, María Del Carmen Ávila-Casado, Mónica X Inofuentes-Rivero, Francisco Rodriguez-Illana, José M Fragoso, Gilberto Vargas-Alarcón
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2014-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320312470579

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https://doi.org/10.1177/1470320312470579

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