The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR.

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR.

BACKGROUND:The antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo. PRINCIPLE FINDING:Niclosamide effectively retarded DENV-i...

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Bibliographic Details
Main Authors: Jo-Chi Kao, Wei-Chun HuangFu, Tsung-Ting Tsai, Min-Ru Ho, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Chiou-Feng Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6117097?pdf=render

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http://europepmc.org/articles/PMC6117097?pdf=render

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