Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

Abstract Background Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets. ATP directly activates the plasma membrane c...

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Bibliographic Details
Main Authors: Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu, Huiyao Lan, Kailang Wu, Jianguo Wu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Biology
Subjects:
Adenosine triphosphate, ATP
P2X7 receptor
Paxillin
The NACHT, LRR, and PYD domain-containing protein 3, NLRP3
Ubiquitin-specific peptidase 13, USP13
Online Access:https://doi.org/10.1186/s12915-020-00918-w

Internet

https://doi.org/10.1186/s12915-020-00918-w

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