Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis

Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis

Abstract Objective To determine the presence and spatial distribution of different macrophage phenotypes, governed by granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) skewing signals, in giant cell arteritis (GCA) lesions. Methods Temporal ar...

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Bibliographic Details
Main Authors: William F Jiemy, Yannick vanSleen, Kornelis SM van derGeest, Hilde A tenBerge, Wayel H Abdulahad, Maria Sandovici, Annemieke MH Boots, Peter Heeringa, Elisabeth Brouwer
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
giant cell arteritis
granulocyte macrophage colony‐stimulating factor
macrophages
macrophage colony‐stimulating factor
vasculitis
Online Access:https://doi.org/10.1002/cti2.1164

Internet

https://doi.org/10.1002/cti2.1164

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