One-Pot Three-Component Synthesis of Novel Diethyl((2-oxo-1,2-dihydroquinolin-3-yl)(arylamino)methyl)phosphonate as Potential Anticancer Agents

One-Pot Three-Component Synthesis of Novel Diethyl((2-oxo-1,2-dihydroquinolin-3-yl)(arylamino)methyl)phosphonate as Potential Anticancer Agents

With the aim of discovering new anticancer agents, we have designed and synthesized novel α-aminophosphonate derivatives containing a 2-oxoquinoline structure using a convenient one-pot three-component method. The newly synthesized compounds were evaluated for antitumor activities against the A549 (...

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Bibliographic Details
Main Authors: Yi-Lin Fang, Zhi-Lin Wu, Meng-Wu Xiao, Yu-Ting Tang, Kang-Ming Li, Jiao Ye, Jian-Nan Xiang, Ai-Xi Hu
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
2-oxoquinoline
α-aminophosphonate
one-pot method
anticancer activity
apoptosis
Online Access:http://www.mdpi.com/1422-0067/17/5/653

Internet

http://www.mdpi.com/1422-0067/17/5/653

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