Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kinase (BTK) PROTAC compounds, we show herein efficient...

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Bibliographic Details
Main Authors: Yamit Shorer Arbel, Ben-Zion Katz, Ronen Gabizon, Amit Shraga, Yotam Bronstein, Talia Kamdjou, Anat Globerson Levin, Chava Perry, Irit Avivi, Nir London, Yair Herishanu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
PROTACs (proteolysis targeting chimeras)
BTK - Bruton’s tyrosine kinase
CLL (Chronic Lymphocytic Leukemia)
ibrutinib
BCR (B cell receptor) signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.646971/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.646971/full

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