Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.

BACKGROUND:The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly...

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Bibliographic Details
Main Authors: Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, Peter T Toth, Michael E Ragozzino, Khuong Le, Haider W Aljewari, Neil M O'Brien-Simpson, Eric C Reynolds, Keiko Watanabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6169940?pdf=render

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http://europepmc.org/articles/PMC6169940?pdf=render

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