ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in...

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Bibliographic Details
Main Authors: Jie Wang, Cristina Zibetti, Peng Shang, Srinivasa R. Sripathi, Pingwu Zhang, Marisol Cano, Thanh Hoang, Shuli Xia, Hongkai Ji, Shannath L. Merbs, Donald J. Zack, James T. Handa, Debasish Sinha, Seth Blackshaw, Jiang Qian
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03856-y

Internet

https://doi.org/10.1038/s41467-018-03856-y

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