Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling

Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling

BackgroundThe exposure of the nucleus pulposus (NP) causes an immune and inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As a newly discovered pro-resolving lipid mediator, maresin 1 (MaR1) could exert powerful inflammatory resolution, neuroprotection, and...

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Bibliographic Details
Main Authors: Yi-hao Wang, Yan Li, Jun-nan Wang, Qing-xiang Zhao, Jin Jin, Shuang Wen, Si-cong Wang, Tao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
radicular pain
maresin 1
NLRP3 inflammasome
pyroptosis
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00831/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00831/full

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