Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy

Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy

Abstract Background Relapsed leukemia following initial therapeutic response and remission is difficult to treat and causes high patient mortality. Leukemia relapse is due to residual quiescent leukemia cells that escape conventional therapies and later reemerge. Eliminating not only growing but qui...

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Bibliographic Details
Main Authors: Bi Liu, Yunzhu Shen, Huafang Huang, Kimiko Della Croce, Min Wu, Yingjuan Fan, Yang Liu, Jianhua Xu, Guang Yao
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Communication and Signaling
Subjects:
Leukemia
Relapse
Quiescence
Dormancy
Curcumin derivative
Hsp90
Online Access:http://link.springer.com/article/10.1186/s12964-020-00652-4

Internet

http://link.springer.com/article/10.1186/s12964-020-00652-4

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