A toolkit for orthogonal and in vivo optical manipulationof ionotropic glutamate receptors

A toolkit for orthogonal and in vivo optical manipulationof ionotropic glutamate receptors

The ability to optically manipulate specific neuronal signaling proteins with genetic precision paves the way for the dissection of their roles in brain function, behavior, and disease. Chemical optogenetic control with photoswitchable tethered ligands (PTLs) enables rapid, reversible and reproducib...

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Bibliographic Details
Main Authors: Joshua Todd Levitz, Andrei ePopescu, Andreas eReiner, Ehud eIsacoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
in vivo
glutamate receptor
Molecular engineering
Chemical Optogenetics
Photo-pharmacology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00002/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00002/full

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