Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion

Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion

Mutations within the Shank3 gene, which encodes a key postsynaptic density (PSD) protein at glutamatergic synapses, contribute to the genetic etiology of defined autism spectrum disorders (ASDs), including Phelan-McDermid syndrome (PMS) and intellectual disabilities (ID). Although there are a series...

Full description

Bibliographic Details
Main Authors: Tian-Jia Song, Xing-Yu Lan, Meng-Ping Wei, Fu-Jun Zhai, Tobias M. Boeckers, Jia-Nan Wang, Shuo Yuan, Meng-Ying Jin, Yu-Fei Xie, Wan-Wen Dang, Chen Zhang, Michael Schön, Pei-Wen Song, Mei-Hong Qiu, Ya-Yue Song, Song-Ping Han, Ji-Sheng Han, Rong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Shank3
Phelan-McDermid syndrome
autism spectrum disorders
intellectual disabilities
social memory
pain threshold
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00111/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00111/full

Similar Items