Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.

The molecular and functional diversity of G protein-coupled receptors is essential to many physiological processes. However, this diversity presents a significant challenge to understanding the G protein-mediated signaling events that underlie a specific physiological response. To increase our under...

Full description

Bibliographic Details
Main Authors: Supriya Srinivasan, Pamela Santiago, Cecile Lubrano, Christian Vaisse, Bruce R Conklin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1930153?pdf=render