A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, constructed in single‐stranded DNA format, a...

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Bibliographic Details
Main Authors: Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Advanced Science
Subjects:
Human alpha‐aminoadipic semialdehyde synthase (AASS)
affinity maturation
cyclic‐AMP response element binding protein (CREBBP)
DNA‐encoded chemical libraries (DEL)
drug discovery
encoded self‐assembling chemical libraries (ESAC)
Online Access:https://doi.org/10.1002/advs.202001970

Internet

https://doi.org/10.1002/advs.202001970

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