Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression

Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression

We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which characteristically contain Myc-activating chromosome translocations and constitutive c-Myc mRNA and protein expression. We examined the nature of c...

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Bibliographic Details
Main Authors: Sabine Mai, Joan Hanley-Hyde, G. Jonah Rainey, Theodore I. Kuschak, James T. Paul, Trevor D. Littlewood, Harald Mischak, Lisa M. Stevens, Darren W. Henderson, J. Frederic Mushinski
Format: Article
Language:English
Published: Elsevier 1999-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Myc
cyclin D2
genomic instability
expression
extrachromosomal elements
Online Access:http://www.sciencedirect.com/science/article/pii/S147655869980044X

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http://www.sciencedirect.com/science/article/pii/S147655869980044X

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