A Cassette Vector System for the Rapid Cloning and Production of Bispecific Tetravalent Antibodies

A Cassette Vector System for the Rapid Cloning and Production of Bispecific Tetravalent Antibodies

Bivalent single chain (sc)Fv-Fc antibodies have been used for years as recombinant alternatives of natural immunoglobulins. We have extended this approach to the scFv-Fc-scFv antibody format to obtain tetravalent antigen binding and the possibility to generate bispecific antibodies. We developed a m...

Full description

Bibliographic Details
Main Authors: Stefanie Claudia Pohl, Steffi Schwarz, André Frenzel, Thomas Schirrmann
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:Antibodies
Subjects:
recombinant antibody
single chain Fv
scFv-Fc-scFv
bispecific antibody
tetravalent antibody, dual specificity
mammalian expression
Online Access:http://www.mdpi.com/2073-4468/1/1/19

Internet

http://www.mdpi.com/2073-4468/1/1/19

Similar Items