Molecular pharmacology of kidney and inner ear CLC-K chloride channels

CLC-K channels belong to the CLC gene family, which comprises both Cl- channels and Cl-/H+ antiporters. They form homodimers which additionally co-assemble with the small protein barttin. In the kidney, they are involved in NaCl reabsorption ; in the inner ear they are important for endolymph produc...

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Bibliographic Details
Main Authors: Antonella eGradogna, Michael ePusch
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-10-01
Series:Frontiers in Pharmacology
Subjects:
clc
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00130/full