Impaired Ca<sup>2+</sup> Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells

Impaired Ca<sup>2+</sup> Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells

Guanylate cyclase-activating protein 1 (GCAP1) is involved in the shutdown of the phototransduction cascade by regulating the enzymatic activity of retinal guanylate cyclase via a Ca<sup>2+</sup>/cGMP negative feedback. While the phototransduction-associated role of GCAP1 in the photorec...

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Bibliographic Details
Main Authors: Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Giorgio Placidi, Elisa De Siena, Benedetto Falsini, Matteo Bertelli, Daniele Dell'Orco
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
GUCA1A
neuronal calcium sensor
phototransduction
synaptic transmission
cone dystrophy
guanylate cyclase
Online Access:https://www.mdpi.com/1422-0067/22/8/4030

Internet

https://www.mdpi.com/1422-0067/22/8/4030

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