Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9

Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9

Enhanced S-cone syndrome (ESCS) is caused by recessive mutations in the photoreceptor cell transcription factor <i>NR2E3</i>. Loss of <i>NR2E3</i> is characterized by repression of rod photoreceptor cell gene expression, over-expansion of the S-cone photoreceptor cell populat...

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Bibliographic Details
Main Authors: Laura R. Bohrer, Luke A. Wiley, Erin R. Burnight, Jessica A. Cooke, Joseph C. Giacalone, Kristin R. Anfinson, Jeaneen L. Andorf, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Genes
Subjects:
induced pluripotent stem cell (iPSC)
clustered regularly interspaced short palindromic repeats (CRISPR)
homology-directed repair (HDR)
Enhanced S-Cone Syndrome (ESCS)
<i>NR2E3</i>
Online Access:https://www.mdpi.com/2073-4425/10/4/278

Internet

https://www.mdpi.com/2073-4425/10/4/278

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