BTLA Expression on Th1, Th2 and Th17 Effector T-Cells of Patients with Systemic Lupus Erythematosus Is Associated with Active Disease

BTLA Expression on Th1, Th2 and Th17 Effector T-Cells of Patients with Systemic Lupus Erythematosus Is Associated with Active Disease

An imbalanced T-cell homeostasis plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Co-stimulatory and co-inhibitory molecules regulate T-cell differentiation, survival, and cytokine production. B- and T-lymphocyte attenuator (BTLA) is a co-inhibitory molecule which n...

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Bibliographic Details
Main Authors: Christoph Oster, Benjamin Wilde, Christof Specker, Ming Sun, Andreas Kribben, Oliver Witzke, Sebastian Dolff
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
SLE
BTLA
Costimulation
IFN-γ
IL-10
IL-17A
Online Access:https://www.mdpi.com/1422-0067/20/18/4505

Internet

https://www.mdpi.com/1422-0067/20/18/4505

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