Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients

Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients

Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial tort...

Full description

Bibliographic Details
Main Authors: Csilla E. Németh, Zsófia Nemoda, Péter Lőw, Pál Szabó, Erzsébet Z. Horváth, Andy Willaert, Annekatrien Boel, Bert L. Callewaert, Paul J. Coucke, Marina Colombi, Gábor Bánhegyi, Éva Margittai
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/8156592

Internet

http://dx.doi.org/10.1155/2019/8156592

Similar Items