Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model

Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease caused by expanded CTG repeats in the 3′ untranslated region (3′UTR) of the DMPK gene. The myogenesis process is defective in DM1, which is closely associated with progressive muscle weakness and wasting. Despite many proposed exp...

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Bibliographic Details
Main Authors: Xiaopeng Shen, Zhongxian Liu, Chunguang Wang, Feng Xu, Jingyi Zhang, Meng Li, Yang Lei, Ao Wang, Chao Bi, Guoping Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Postn
myotonic dystrophy type 1
microenvironment
myoblast
myogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.710112/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.710112/full

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