Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

Viruses hijack host machinery and regulate cellular homeostasis to actively replicate their genome, propagate, and cause disease. In retaliation, cells possess various defense mechanisms to detect, destroy, and clear infecting viruses, as well as signal to neighboring cells to inform them of the imm...

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Bibliographic Details
Main Authors: Svenja Fritzlar, Turgut E. Aktepe, Yi-Wei Chao, Nathan D. Kenney, Michael R. McAllaster, Craig B. Wilen, Peter A. White, Jason M. Mackenzie
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.00960-19