TNFα inhibitors as targets for protective therapies in MSA: a viewpoint

TNFα inhibitors as targets for protective therapies in MSA: a viewpoint

Abstract Multiple system atrophy (MSA) is a unique and fatal α-synucleinopathy associated with oligodendroglial inclusions and secondary neurodegeneration affecting striatum, substantia nigra, pons, and cerebellum. The pathogenesis remains elusive; however, there is emerging evidence suggesting a pr...

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Bibliographic Details
Main Authors: Alain Ndayisaba, Kurt Jellinger, Thomas Berger, Gregor K. Wenning
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Neuroinflammation
Subjects:
TNFα
TNFα inhibitors
Multiple system atrophy
Neuroinflammation
Neurodegeneration
Disease-modifying treatment
Online Access:http://link.springer.com/article/10.1186/s12974-019-1477-5
Description
Summary:Abstract Multiple system atrophy (MSA) is a unique and fatal α-synucleinopathy associated with oligodendroglial inclusions and secondary neurodegeneration affecting striatum, substantia nigra, pons, and cerebellum. The pathogenesis remains elusive; however, there is emerging evidence suggesting a prominent role of neuroinflammation. Here, we critically review the relationship between αS and microglial activation depending on its aggregation state and its role in neuroinflammation to explore the potential of TNFα inhibitors as a treatment strategy for MSA and other neurodegenerative diseases.
ISSN:1742-2094

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