Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

Abstract Background Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification is critical to neutrophil sequestration in liver sinusoids and to survi...

Full description

Bibliographic Details
Main Authors: Kevin Ni, Amar Gill, Victor Tseng, Andrew M. Mikosz, Kengo Koike, Erica L. Beatman, Cassie Y. Xu, Danting Cao, Fabienne Gally, Kara J. Mould, Karina A. Serban, Kelly S. Schweitzer, Keith L. March, William J. Janssen, Eva Nozik-Grayck, Stavros Garantziotis, Irina Petrache
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Respiratory Research
Subjects:
Extracellular matrix
Hyaluronic acid
Inter-alpha-inhibitor
Serum-derived hyaluronan-associated protein
TNFα stimulated gene 6
Lung inflammation
Online Access:http://link.springer.com/article/10.1186/s12931-018-0812-1

Internet

http://link.springer.com/article/10.1186/s12931-018-0812-1

Similar Items