Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Transgenic mice made by crossing animals expressing mutant amyloid precursor protein (APPswe) to mutant presenilin 1 (PS1dE9) allow for incremental increases in Aβ42 production and provide a model of Alzheimer-type amyloidosis. Here, we examine cognition in 6- and 18-month old transgenic mice expres...

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Bibliographic Details
Main Authors: Alena Savonenko, Guilian M. Xu, Tatiana Melnikova, Johanna L. Morton, Victoria Gonzales, Molly P.F. Wong, Donald L. Price, Fai Tang, Alicja L. Markowska, David R. Borchelt
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neurobiology of Disease
Subjects:
Aging
Radial Water Maze
Cholinergic system
Somatostatin
Factor analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002669

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http://www.sciencedirect.com/science/article/pii/S0969996104002669

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