Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

Background: Nephrotoxicity is a notable adverse effect in cisplatin treated patients characterized by tubular injury and/or increased serum creatinine (SCr) with incidence varying from 20 to 70%. Pharmacogenomics has been shown to identify strongly predictive genetic markers to help determine which...

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Bibliographic Details
Main Authors: Zulfan Zazuli, Susanne Vijverberg, Elise Slob, Geoffrey Liu, Bruce Carleton, Joris Veltman, Paul Baas, Rosalinde Masereeuw, Anke-Hilse Maitland-van der Zee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
cisplatin
nephrotoxicity
genetic variations
pharmacogenomics
precision medicine
kidney
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01111/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01111/full

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