Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I-mediated anti...

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Bibliographic Details
Main Authors: Wei Liu, Jing Li, Weinan Zheng, Yingli Shang, Zhendong Zhao, Shanshan Wang, Yuhai Bi, Shuang Zhang, Chongfeng Xu, Ziyuan Duan, Lianfeng Zhang, Yue L Wang, Zhengfan Jiang, Wenjun Liu, Lei Sun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
Cyclophilin A
RIG-I
ubiquitination
Antiviral Immunity
Online Access:https://elifesciences.org/articles/24425

Internet

https://elifesciences.org/articles/24425

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