Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I-mediated anti...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-06-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/24425 |