Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity

Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity

The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus replicates and activates human macrophages, the pathoge...

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Bibliographic Details
Main Authors: María F. Ferrer, Pablo Thomas, Aída O. López Ortiz, Andrea E. Errasti, Nancy Charo, Victor Romanowski, Juan Gorgojo, María E. Rodriguez, Eugenio A. Carrera Silva, Ricardo M. Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
junin virus
human macrophages
TAM receptors
macrophage activation
macrophage polarization
IFN-I
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02499/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02499/full

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