Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease

Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease

Akt kinase isoforms (Akt1, Akt2, and Akt3) have generally been thought to play overlapping roles in phosphoinositide 3-kinase (PI3K)-mediated-signaling. However, recent studies have suggested that they display isoform-specific roles in muscle and fat. To determine whether such isoform-specificity is...

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Bibliographic Details
Main Authors: Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Ying Cheng, Joseph Ibrahim, Pamela L. Tuma
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
akt1
akt2
akt3
akt isoforms
alcoholic liver disease
liver fibrosis
inflammation
proliferation
migration
Online Access:https://www.mdpi.com/2073-4409/8/11/1337

Internet

https://www.mdpi.com/2073-4409/8/11/1337

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