A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

In a multiscale simulation of a beating heart, the very large difference in the time scales between rapid stochastic conformational changes of contractile proteins and deterministic macroscopic outcomes, such as the ventricular pressure and volume, have hampered the implementation of an efficient co...

Full description

Bibliographic Details
Main Authors: Kazunori Yoneda, Jun-ichi Okada, Masahiro Watanabe, Seiryo Sugiura, Toshiaki Hisada, Takumi Washio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
heart simulation
Monte Carlo method
finite element method
excitation contraction coupling
multiple time step method
active stiffness
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.712816/full

Similar Items

Similar Items