Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders. Previously, we found that CRISPR/Cas9 based editing of the TAF1 gene disrupts the morp...

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Bibliographic Details
Main Authors: Chinnasamy Dhanalakshmi, Udaiyappan Janakiraman, Aubin Moutal, Kohji Fukunaga, Rajesh Khanna, Mark A. Nelson
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Neurobiology of Disease
Subjects:
TAF1
Intellectual disability syndrome
SAK3
CaV3.1
Cerebral cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030499X

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http://www.sciencedirect.com/science/article/pii/S096999612030499X

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