Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestinal crypt cell regeneration. Motivated by the observ...

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Bibliographic Details
Main Authors: Xin Zeng, Robert Kirkpatrick, Glenn Hofmann, Didier Grillot, Valerie Linhart, Fabrice Viviani, Joseph Marino, Joseph Boyer, Taylor L Graham, Quinn Lu, Zining Wu, Andrew Benowitz, Rick Cousins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207140

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https://doi.org/10.1371/journal.pone.0207140

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