Endometrial stromal sarcomas with BCOR‐rearrangement harbor MDM2 amplifications

Endometrial stromal sarcomas with BCOR‐rearrangement harbor MDM2 amplifications

Abstract Recently a novel subtype of endometrial stromal sarcoma (ESS) defined by recurrent genomic alterations involving BCOR has been described (HGESS‐BCOR). We identified a case of HGESS‐BCOR with a ZC3H7B‐BCOR gene fusion, which harbored an amplification of the MDM2 locus. This index case prompt...

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Bibliographic Details
Main Authors: Felix KF Kommoss, Kenneth TE Chang, Damian Stichel, Ana Banito, David TW Jones, Christoph E Heilig, Stefan Fröhling, Felix Sahm, Albrecht Stenzinger, Wolfgang Hartmann, Gunhild Mechtersheimer, Hans‐Peter Sinn, Dietmar Schmidt, Friedrich Kommoss, Andreas vonDeimling, Christian Koelsche
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
endometrial stromal sarcoma
MDM2
amplification
BCOR
YWHAE
uterine
Online Access:https://doi.org/10.1002/cjp2.165

Internet

https://doi.org/10.1002/cjp2.165

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