MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia

MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia

Vulvar cancer is the fourth most common gynecological cancer worldwide. However, limited studies have been completed on the molecular characterization of vulvar squamous cell carcinoma resulting in a poor understanding of the disease initiation and progression. Analysis and early detection of the pr...

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Bibliographic Details
Main Authors: Chao Zhang, Georgia Arentz, Lyron Winderbaum, Noor A. Lokman, Manuela Klingler-Hoffmann, Parul Mittal, Christopher Carter, Martin K. Oehler, Peter Hoffmann
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
Matrix-assisted laser desorption/ionization (MALDI)
imaging mass spectrometry (MSI)
differentiated vulvar intraepithelial neoplasia (dVIN)
vulva squamous cell carcinomas (VSCC)
Cytokeratin 5 (CK5)
Online Access:http://www.mdpi.com/1422-0067/17/7/1088

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http://www.mdpi.com/1422-0067/17/7/1088

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