An RBPJ-<i>Drosophila</i> Model Reveals Dependence of RBPJ Protein Stability on the Formation of Transcription–Regulator Complexes

Notch signaling activity governs widespread cellular differentiation in higher animals, including humans, and is involved in several congenital diseases and different forms of cancer. Notch signals are mediated by the transcriptional regulator RBPJ in a complex with activated Notch (NICD). Analysis...

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Bibliographic Details
Main Authors: Bernd M. Gahr, Franziska Brändle, Mirjam Zimmermann, Anja C. Nagel
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/8/10/1252