5-aza-2′-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma

5-aza-2′-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma

Background: Neuroblastoma (NB) is one of the most common malignant solid tumors to occur in children, characterized by a wide range of genetic and epigenetic aberrations. We studied whether modifications of the latter with a 5-aza-2′-deoxycytidine (decitabine, Dac) DNA methyltransferase inhibitor ca...

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Bibliographic Details
Main Authors: Hung-Yu Lin, Jiin-Haur Chuang, Pei-Wen Wang, Tsu-Kung Lin, Min-Tsui Wu, Wen-Ming Hsu, Hui-Ching Chuang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
neuroblastoma
DNA methyltransferase inhibitor
innate immune response
mitochondria
double-stranded RNA
Online Access:https://www.mdpi.com/2073-4409/9/9/1920

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https://www.mdpi.com/2073-4409/9/9/1920

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