Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to ensnare and kill invading pathogens, and has been recently termed NETosis. Neutrophils can be stimulat...

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Bibliographic Details
Main Authors: Anthony J O'Donoghue, Ye Jin, Giselle M Knudsen, Natascha C Perera, Dieter E Jenne, John E Murphy, Charles S Craik, Terry W Hermiston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3779220?pdf=render

Internet

http://europepmc.org/articles/PMC3779220?pdf=render

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