Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution

Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution

Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carriers, stabilized by a dextran shell, were developed t...

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Bibliographic Details
Main Authors: Susanne Heid, Harald Unterweger, Rainer Tietze, Ralf P. Friedrich, Bianca Weigel, Iwona Cicha, Dietmar Eberbeck, Aldo R. Boccaccini, Christoph Alexiou, Stefan Lyer
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
protein binding
activated ester reaction
fibrinolysis
tissue plasminogen activator
superparamagnetic iron oxide nanoparticles
drug targeting
Online Access:https://www.mdpi.com/1422-0067/18/9/1837

Internet

https://www.mdpi.com/1422-0067/18/9/1837

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