Chitosan-DNA nanoparticles enhanced the immunogenicity of multivalent DNA vaccination on mice against Trueperella pyogenes infection

Chitosan-DNA nanoparticles enhanced the immunogenicity of multivalent DNA vaccination on mice against Trueperella pyogenes infection

Abstract Background Trueperella pyogenes is a commensal and opportunistic pathogen that normally causes mastitis, liver abscesses and pneumonia of economically important livestock. To develop efficacious and potent vaccine against T. pyogenes, chimeric gene DNA vaccines were constructed and encapsul...

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Bibliographic Details
Main Authors: Ting Huang, Xuhao Song, Jie Jing, Kelei Zhao, Yongmei Shen, Xiuyue Zhang, Bisong Yue
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Nanobiotechnology
Subjects:
Trueperella pyogenes
DNA vaccine
Chitosan nanoparticles
CpG motifs
Virulence factors
Multi-valency
Online Access:http://link.springer.com/article/10.1186/s12951-018-0337-2

Internet

http://link.springer.com/article/10.1186/s12951-018-0337-2

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