LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.

The leucine-rich repeat kinase 2 (LRRK2) gene was found to play a role in the pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 encodes a large multi-domain protein that is expressed in different tissues. To date, the physiological and pathological functions of LRRK2 ar...

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Bibliographic Details
Main Authors: Rossana Migheli, Maria Grazia Del Giudice, Ylenia Spissu, Giovanna Sanna, Yulan Xiong, Ted M Dawson, Valina L Dawson, Manuela Galioto, Gaia Rocchitta, Alice Biosa, Pier Andrea Serra, Maria Teresa Carri, Claudia Crosio, Ciro Iaccarino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805556?pdf=render

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http://europepmc.org/articles/PMC3805556?pdf=render

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