In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

Activity of the oxidative phosphorylation system (OXPHOS) is decreased in humans and mice with nonalcoholic steatohepatitis. Nitro-oxidative stress seems to be involved in its pathogenesis. The aim of this study was to determine whether fatty acids are implicated in the pathogenesis of this mitochon...

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Bibliographic Details
Main Authors: Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Teresa Muñoz-Yagüe, José A. Solís-Herruzo
Format: Article
Language:English
Published: The Company of Biologists 2015-02-01
Series:Disease Models & Mechanisms
Subjects:
Mitochondrial respiratory chain
Nonalcoholic steatohepatitis
NADPH oxidase
Oxidative phosphorylation
Proteomic
Nitro-oxidative stress
OXPHOS
Online Access:http://dmm.biologists.org/content/8/2/183

Internet

http://dmm.biologists.org/content/8/2/183

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