Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens

Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens

Detecting the entire repertoire of tumor-specific reactive tumor-infiltrating lymphocytes (TILs) is essential for investigating their immunological functions in the tumor microenvironment. Current in vitro assays identifying tumor-specific functional activation measure the upregulation of surface mo...

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Bibliographic Details
Main Authors: Arianna Draghi, Christopher Aled Chamberlain, Shawez Khan, Krisztian Papp, Martin Lauss, Samuele Soraggi, Haja Dominike Radic, Mario Presti, Katja Harbst, Aishwarya Gokuldass, Anders Kverneland, Morten Nielsen, Marie Christine Wulff Westergaard, Mads Hald Andersen, Istvan Csabai, Göran Jönsson, Zoltan Szallasi, Inge Marie Svane, Marco Donia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
CD137 (4-1BB)
immune-responses to cancer
tumor-specific activation
tumor-specific reactivity
single-cell technologies
tumor-infiltrating lymphocytes (TILs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705422/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.705422/full

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