Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development

Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development

Metabolism plays a critical role in direct regulation of a variety of cellular activities via metabolic enzymes and metabolites. Here, we demonstrate that phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in glycolysis, promotes EGFR activation-induced nuclear t...

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Bibliographic Details
Main Authors: Jong-Ho Lee, Fei Shao, Jinjie Ling, Sean Lu, Rui Liu, Linyong Du, Jin Woong Chung, Sang Seok Koh, Sun-Hee Leem, Jichun Shao, Dongming Xing, Zhiqiang An, Zhimin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
PFKP
β-catenin
c-Myc
cyclin D1
migration
invasion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00211/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00211/full

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