Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

B lymphocyte development occurs in the bone marrow, while final differentiation and maturation can occur in both the bone marrow and the spleen. Here we provide evidence that signal regulatory protein α (SIRPα), an Ig-superfamily ITIM-receptor expressed by myeloid but not by lymphoid cells, is invol...

Full description

Bibliographic Details
Main Authors: Shrikant Shantilal Kolan, Kristina Lejon, Cecilia Koskinen Holm, Rima Sulniute, Pernilla Lundberg, Takashi Matozaki, Per-Arne Oldenborg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4519279?pdf=render

Internet

http://europepmc.org/articles/PMC4519279?pdf=render

Similar Items